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By 2030, obesity could affect more than half of the US population.1

Obesity is often an underlying issue behind several of the most common costly, and potentially deadly, health conditions.2  Evidence shows that a decrease in BMI reduces annual medical expenditures and is likely to result in clinically meaningful health benefits.3

At Nestlé Health Science, we are actively engaged in developing nutritional therapies to help reduce obesity and its associated comorbidities, while improving the quality of life of those who are challenged by the condition. 

About Obesity

Obesity is a growing public health concern. According to the CDC, nearly 1 in 3 adults (30.7%) are overweight and 42.4% are obese.  This includes 9.2% who are classified as severely obese.4

Obesity is a chronic disease strongly linked to conditions including type 2 diabetes, hypertension, stroke, metabolic syndrome, obstructive sleep apnea, Non-Alcoholic Fatty Liver Disease (NAFLD), Non-Alcoholic Steatohepatitis (NASH), coronary heart disease and osteoarthritis. Modest sustained body weight loss ranging from 5 – 15% is likely to result in clinically meaningful health benefits in individuals with those conditions.5



Non-Alcoholic Fatty Liver Disease (NAFLD) and its advanced stage, Non-Alcoholic Steatohepatitis (NASH), are becoming increasingly prevalent, affecting an estimated 30% and 5% respectively, of people worldwide and presenting significant health challenges.6 NAFLD encompasses a spectrum of conditions, ranging from steatosis to cirrhosis7 and is characterized by the presence of excessive hepatic fat accumulation ≥5%8 and associated with insulin resistance in the absence of other recognized causes of fatty liver (e.g., alcohol, virus, drugs, autoimmunity).7


There are no approved pharmacological interventions available for NAFLD7,8,9, however emerging research has shown that weight loss of at least +10% can have profound effects on these conditions. Shedding excess weight through a balanced approach of dietary modifications and regular physical activity has demonstrated the potential to reverse liver fat accumulation, inflammation, and fibrosis.10 As healthcare professionals, understanding the intricate interplay between weight loss and liver health is paramount in guiding patients towards improved outcomes and fostering healthier futures.



Obesity, particularly excess abdominal fat, triggers insulin resistance, leading to impaired glucose regulation. As a result, individuals with obesity face a substantially heightened risk of developing type 2 diabetes (T2DM).11

One out of nine individuals in the US population (37 million people) have diabetes. Most of them are diagnosed with T2DM.12

However, by reducing obesity through evidence-based weight-loss strategies such as lifestyle modifications, personalized nutrition or diet replacement programs, and increased physical activity, healthcare professionals can empower patients to significantly reduce their risk of type 2 diabetes and its associated complications.13,14,15,16,17,18

Nutrition & OBESITY

While there is no single approach to treating obesity, experts agree that the first step toward achievement of successful weight loss and maintenance is a comprehensive lifestyle approach that includes dietary modification, physical activity and behavioral therapy.8,9,19



For overweight patients, a balanced approach to nutrition management is often appropriate. Emphasizing the importance of a well-rounded, nutritious diet can help patients achieve gradual weight loss while building healthy habits for the long term. Encouraging portion control, mindful eating, and incorporating regular physical activity can further complement these efforts. Meal replacement programs, consisting of nutritionally formulated shakes or bars, may be considered as adjuncts to conventional dietary strategies. These programs can provide convenient and structured options that help patients control their caloric intake while ensuring essential nutrient requirements are met. Close monitoring and personalized support from healthcare providers are essential for sustainable success in this population.

Components of weight loss


Obese and severely obese patients may face more complex challenges that require a more comprehensive weight-loss approach. Meal replacement programs, under proper medical supervision, can be a valuable tool in the initial phase of weight loss for severely obese individuals. These programs may help to rapidly reduce caloric intake, which can be motivating for patients, facilitate significant weight loss20, and can help reduce blood glucose levels.21,22

However, due to the severity of obesity and potential underlying health issues, a multidisciplinary approach can be most effective. Collaboration between dietitians, psychologists, and other healthcare specialists can address psychological and behavioral factors related to overeating, enabling long-term success. Additionally, emphasizing behavior modification, setting realistic goals, and encouraging increased physical activity can foster lasting lifestyle changes that support sustained weight loss and overall well-being.

At Nestlé Health Science, we collaborate with key opinion leaders, healthcare providers, and researchers to develop nutritional solutions for weight management and associated health conditions. Through extensive research and innovation, we have created tailored programs, products, and meal replacements that empower patients to achieve lasting results and improved overall health.

Support Resources

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Meal Replacement Products

Meal replacement products can be used in obesity management to provide a controlled and calorie-restricted option for patients, helping them achieve weight loss goals while ensuring essential nutrients are delivered in a convenient and balanced manner.

Modular Supplements

Modular nutrition products offer a flexible and versatile approach to obesity treatment, allowing healthcare professionals to tailor nutritional support based on patients' specific needs. These specialized components, when incorporated into a balanced diet, support various aspects of health such as providing additional fiber to help support digestive health and normal bowel function or providing additional protein to support muscle maintenance or aid in wound healing.


1. Ward ZJ, Bleich SN, Cradock AL et al.  Projected U.S. State-Level Prevalence of Adult Obesity and Severe Obesity. N Engl J Med. 2019 Dec 19;381(25):2440-2450.
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3. Thorpe, K; Toles, A; Shah, Bimal et al.  Weight Loss-Associated Decreases in Medical Care Expenditures for Commercially Insured Patients With Chronic Conditions. Journal of Occupational and Environmental Medicine: October 2021, 63 (10); 847-851
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