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Improved Growth in Children Receiving Long-Term Enteral Nutrition: 100% Whey Protein Peptide-Based Enteral Formulas

Peptamen® peptide-based enteral formula range

A retrospective chart review of pediatric patients receiving Peptamen® products for ≥30 days found that 100% whey protein peptide-based enteral formulas were associated with improved growth outcomes, high nutritional goal attainment, and advancement toward oral feeding in children with complex GI conditions.

Poster Summary

Tolerance and Weight Gain with 100% Whey Protein Peptide Based Enteral Formulas in Pediatric Population: A Retrospective Review

A Research Summary based on Elfadil OM, Jogani VG, Johnson DA, et al. JPEN. 2026; 50(S1): S322–S323.

Background

While available evidence indicates improved tolerance and clinical benefit, there remains a lack of data specifically examining the effects of 100% whey protein peptide-based formulas on growth and anthropometric outcomes in pediatric patients receiving long-term enteral nutrition.1,2

Methods

Retrospective chart review in pediatric patients receiving Peptamen® products for ≥30 days. Data collected included underlying diagnoses, measures of nutritional adequacy, and clinical outcomes.

Most Common Underlying Conditions

 

32.5% Congenital/developmental delay

 

27% Malignancy-related conditions

 

27% Other

 

13.5% Dysmotility

Results

Delivered Nutrition
Delivered Nutrition: patients met 95% (±11.3%) of target volume/calorie goals and 92% (±20.6%) of target protein goals
Achieved Oral Autonomy
Achieved Oral Autonomy: 43% of patients
Median Growth / Per 100 Days
Median Growth per 100 Days: +5.88% change in baseline weight; +0.17 change in weight-for-age z-scores
 
Conclusion

These findings suggest that Peptamen® represents an effective and clinically meaningful nutritional strategy for pediatric patients requiring enteral support, particularly in the context of feeding intolerance, and may facilitate both growth recovery and advancement toward oral feeding.

USE UNDER MEDICAL SUPERVISION