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Ketogenic Diet

Epilepsy is a disease characterized by recurrent seizures. While many patients with epilepsy have good seizure control with medication, approximately 30% fail to respond to two or more anti-epileptic drugs (AED’s)1, 2. For these individuals, the ketogenic diet may be recommended. This is a very high fat, very low carbohydrate, adequate protein diet that causes a shift from carbohydrate to fat metabolism. The dietary change from the production and utilization of glucose generates ketones (i.e. keto-genic) for use as an alternative fuel source for the brain and other tissues. The precise mechanism by which the ketogenic diet works is still not fully understood, although the intake of a high proportion of daily energy requirements from fat combined with a low intake of carbohydrate appears crucial.

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Ketogenic Diet

Epilepsy is a disease characterized by recurrent seizures. While many patients with epilepsy have good seizure control with medication, approximately 30% fail to respond to two or more anti-epileptic drugs (AED’s)1, 2. For these individuals, the ketogenic diet may be recommended. This is a very high fat, very low carbohydrate, adequate protein diet that causes a shift from carbohydrate to fat metabolism. The dietary change from the production and utilization of glucose generates ketones (i.e. keto-genic) for use as an alternative fuel source for the brain and other tissues. The precise mechanism by which the ketogenic diet works is still not fully understood, although the intake of a high proportion of daily energy requirements from fat combined with a low intake of carbohydrate appears crucial.

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Ketogenic Diet
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1. Granata T, Marchi N, Carlton E, Ghosh C, Gonzalez-Martinez J, Alexopoulos AV, et al. Management of the patient with medically refractory epilepsy. Expert review of neurotherapeutics. 2009;9(12):1791-802.

2. Martin K, Jackson CF, Levy RG, Cooper PN. Ketogenic diet and other dietary treatments for epilepsy. The Cochrane database of systematic reviews. 2016;2:CD001903.